ORODISPERSIBLE TABLETS OF ANTI-ALLERGIC CETIRIZINE: A COMPREHENSIVE REVIEW

Abstract

Allergic disorders represent a major global health burden affecting individuals of all age groups. Cetirizine hydrochloride, a second-generation antihistamine, is extensively prescribed due to its high efficacy and relatively low sedative effect [1]. However, conventional oral dosage forms present challenges such as swallowing difficulty and delayed onset of action. Orodispersible tablets (ODTs) have emerged as an innovative oral drug delivery system designed to improve patient compliance and therapeutic effectiveness [2]. This comprehensive review discusses the pathophysiology of allergic disorders, pharmacology of cetirizine, formulation strategies, excipients, manufacturing techniques, evaluation parameters, clinical significance, regulatory considerations, recent advances, and future prospects of cetirizine orodispersible tablets